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Heifermate Technology



Heifermate is a liquid dosage formula. It is a chemical composition that contains certain acive constituents that have the capability to fix the selective combination of desired chromatin containing spertozoa with the ovum. This is achieved by blocking the receptor sites for the undesired spermatozoa on the binding sites for those spermatozoa on the surface of body of the ocum. The technology involves about the production of certain YSBLM (Y sperm binding ligand mimics) in the plasma of the female animal just before conception. The chemical composition of Heifermate consists of chemicals of sodium ethanoate and ethanoic acid which are known sex fixers in prior art in scientific history. The sodium ethanoate and ethanoic acid solution is a sex ratio manipulator (US patent no. 7351581). It produces predominantly female zygotes and this action is enhanced when this is used in combination with each other rather than when both ingredients used independently. The differential binding of X and Y chromosome bearing sperms with different binding moieties is a well known phenomenon in the scientific history (U.S. patents 4,448,767 and 4,999,283). These differntial binding ligands on X and Y sperms may be in conformation to the selective receptor binding sites on the body of the ovum (Proccedings of VIII th annual conference of ISVPT 2008, page 194 and proceedings of the ‘National seminar on emerging opportunities for commercializing in dairying’, in NDRI in 2008, page 146). The more such evidence exists in research publications (Pashudhan, vol. 34:04, page 08. 2008 and Proceedings of the 15th Congress of FAVA, Bangkok, Thailand. 2008). The sex ratio manipulator action of sodium ethanoate and ethanoic acid in combination and separately, is also tabulated in Australian patent no. 2001235973, New Zealand patent no. 526489, South African patent no. 2003/4623 and Canadian patent no. 2432,172). There are certain other indications of these compounds. Sodium ethanoate is a known isotonic, used in dialysis (IP 2007. Page 1701). Ethanoate group is known to facilitate the speedy recovery of liver and skeletal muscle glycogen and is often taken by athletes to enhance performance (Takashi et al. 2001. J Nutr. Page 1973-77.). Ethanoic acid is used in the prepration of ear drops (IP 2007. Page 685). Intake of acetate enhances the intestinal absorption of calcium (Kishi et al. 1999. Biosci Biotechnol Biochem. 63: 905-10.). Wheras sodium is the important ingredient in various metabolic activities of the body and even an important constituent of the various mechanisms involving the nerve impulses and plays a key factor maintaining the well known neuro physiological voltage gradiant. Sodium is taken in sufficient quantities by living organisms on daily basis as sodium chloride. Sodium ethanoate when ingested orally by ruminants provides ethanoate radical which is immediately biotransformed into ethanoic acid which by itself is a big source of energy and also is already present in the rumen due to bacterial metabolism going on in the rumen. This acts as a precursor of selective sperm binding ligand mimic moities, YSBLM (Ysperm binding ligand mimics) (Aulakh BS, 2009. Sex Fixing: The Dawn of a New Era. Studium Press. New Delhi. Page, 72-94) and along with ethanoic acid forms a buffer system as well and thereby acts as a selective sex ratio manipulator on the predominantly female side (US patent no. 7351581, Australian patent no. 2001235973, New Zealand patent no. 526489, South African patent no. 2003/4623 and Canadian patent no. 2432,172 etc). Dilute ethanoic acid is an expectorant, anti bacterial, antifungal and escharotic as already known in the prior art in scientific community.

PHARMACODYNAMICS
Sodium ethanoate is readily dissociable into sodium and ethanoate ions in the rumen and thereby as ethanoic acid takes an important part in the energy cycle. It is metabolised via acetyl-Co-enzyme-A in the tricoboxylic cyle in the liver and skeletal muscles (Crabtree et al.1990. Biochem J. 270: 219-25.). The generation of selective sperm specific binding ligand mimic moities, YSBLM, produces the preferential skewing of sex ratios in ruminants (US patent no. 7351581, Australian patent no. 2001235973, New Zealand patent no. 526489, South African patent no. 2003/4623 and Canadian patent no. 2432,172). The other outcomes of it are energy supplementation.

The clinical studies have revealed the sperm binding ligand action to be of the selective nature (Aulakh, BS. 2009. Sex Fixing: The Dawn of a New Era. Studium Press. New Delhi. Page 72-94). In higher ruminants, it has been demonstrated that the binding ligand mimic moities are of the Y sperm inhibiting type, thereby resulting in the preferential production of female sexed progenies. Such extensive trials have already been undertaken with the outcome of successful sex fixing action of this formula, producing female calves in greater numbers (Punjab Govt, Directorate of Animal Husbandry document no. 6/58/08/D-4/22076, Tamil Nadu Govt, Commissionerate of Animal Husbandry, document no. 4692/H-1/09, J & K Govt, Deptt of Animal Husbandry, leter dated 11/03/2009 and CVAS, Rajasthan AgricultureUniversity, Bikaner letters dated 15/10/2007 and 05/04/2008. The different physical, physiological factors, features, mechanisms etc that play an important part in the process of sex fixing of this formula, are discussed in detail in ‘Super Science & Playing God’ by Aulakh, BS. 2011. Published by Lucius Santino Publications, Ludhiana, and ‘Sex Fixing: The Dawn of a New Era, page 59-94’ just mentioned above.

PHARMACOKINETICS
Absorption: Sodium ethanoate is very good eletrolyte and is almost entirely dissociable in the aquous systems and that is the reason that in rumen, it causes a lot of ethanoic ions which are readily taken in the energy mechanism as ethanoic acid. The mean oral bioavailability is more than 90%. Sodium ion takes part in the isotonic equilibrium in rumen as well and ethanoate is readily absorbed in blood.

Distribution: The ethanoic acid is readily taken in the plasma and it binds to the plasma proteins by more than 99%. It becomes uniformly distributed throughout the plasma in the living system. The uptake of ethanoate happens in the liver and skeletal muscles and it also spreads in the entire blood system.

Biotransformation: The sodium ethanoate is extensively metabolised. The sodium is taken into the ionophoric, isotonic systems and also supplemented in the nervous impulse conductivity mechanisms. The ethanoate is changed into ethanoic acid and becomes a direct participant in the Krebs’ cycle via the tricoboxylic acid cycle and results in the release of energy. This interferenc with the Krebs’ cycle probably causes the release of certain selective sperm binding ligand mimic moities in ruminants.

Elimination: The various constituents and metabolites of sodium ethanoate in body are are eliminated almost entirely within the 24-48 hours after administration. Sodium is taken into the sodium metabolism and ethanoate into the Krebs’ cycle. The available data reveals that the clinically effective concentrations are present in the body for a period of up to 16 hours after administration.